LMU Klinikum München

In April 2020, the LMU Klinikum München in Munich, Germany, started the prospective COVID-19 cohort study Munich (KoCo19) in cooperation with two partners. For the serological analysis of the blood samples the researchers used the two EUROIMMUN Anti-SARS-CoV-2 ELISAs IgA and IgG (see published protocol). In the study, venous blood samples as well as capillary blood from the fingertip were investigated. Both samples types can be analysed with the ELISAs.

Further information on the study (german)


Indian Council of Medical Research (ICMR)

On 4th June, the Indian Council of Medical Research (ICMR), one of the most relevant medical institutions in India and central Institution in the fight against the COVID-19 pandemic, declared that they have validated three test systems for the detection of IgG antibodies against SARS-CoV-2, among others the EUROIMMUN Anti-SARS-CoV-2 ELISA (IgG), and approved them for seroprevalence studies on SARS-CoV-2 in population groups at risk in India.

The article


Public Health England

Also Public Health England, an executive agency of the Department of Health and Social Care in the United Kingdom are now applying the EUROIMMUN-Anti-SARS-CoV-2 ELISA (IgG) to monitor the seroprevalence of anti-SARS-CoV-2 antibodies in the British population.

Report Public Health England


LabCorp

LabCorp, a leading global life sciences company with headquarters in the US, has also opted to use the Anti-SARS-CoV-2 ELISA (IgG) from EUROIMMUN and has been offering a “Return to Work” service for employers since 14th May. This includes, among other services, testing for antibodies against the new coronavirus using a kit for at-home sampling by the user (collection of a blood drop from the fingertip) and the subsequent laboratory blood analysis by means of the EUROIMMUN ELISA.

Press release LabCorp


Sonora Quest Laboratories

On 8th May 2020, Sonora Quest Laboratories, the market share leader in diagnostic laboratory testing in Arizona, announced they have started performing COVID-19 antibody tests. Sonora Quest also opted to use the Anti-SARS-CoV-2 ELISA (IgG). The laboratory stated they will start off by performing approximately 3,000 determinations per day and expand their capacities step by step.

Press release Sonora Quest Laboratories


ARUP Laboratories

ARUP Laboratories, a leading national reference laboratory in the US with customers all over the country, has been using the Anti-SARS-CoV-2 ELISA (IgG) as a second antibody test for COVID-19 diagnostics since 13th May 2020. “The EUROIMMUN test can also help clinicians understand the level of the antibody response and the duration of long-lasting immunity to the disease” says ARUP’s chief medical officer Julia Delgado in their press release.

Press release ARUP Laboratories


Beaumont Health

Beaumont Health, the largest healthcare provider in Michigan, US, has performed internal validation studies on the EUROIMMUN Anti-SARS-CoV-2 ELISA IgG and now uses it for the most comprehensive serological study in the US. First, 38,000 employees of Beaumont and patients shall be tested. Subsequently, the test systems shall also be provided to other hospitals.

Press release Beaumont Health


Quest Diagnostics

Quest Diagnostics, one of the largest laboratory chains worldwide is convinced of the good quality of the Anti-SARS-CoV-2 ELISA (IgG) after performing their own validation studies and now uses the EUROIMMN ELISA in the testing of blood samples for infections with SARS-CoV-2 (COVID-19).

Presse release Quest Diagnostics


University Clinic Bonn “Heinsberg study”

The “Heinsberg study” was realised in the municipality of Gangelt (North Rhine-Westphalia) by Prof. Dr. Hendrik Streeck and Prof. Dr. Gunther Hartmann from the University of Bonn and their research team. More than 900 persons were tested for COVID-19, among others using the Anti-SARS-CoV-2 ELISA. The study confirmed the high specificity of the EUROIMMUN ELISA and showed a good correlation with a neutralisation assay.

Study results


University Clinical Centre Hamburg Eppendorf

Prof. Lohse, Clinical Director of the 1st Medical Clinic and Polyclinic (Gastroenterology with the Infectiology and Tropical Medicine sections) at the University Clinical Centre Hamburg Eppendorf and his team analysed more than 1100 blood samples from employees using the Anti-SARS-CoV-2 ELISA IgG. At a press conference on 22 April 2020 he reported on the results and summarised as follows: “The test appears to be specific, even very specific.”

Publications

  1. Amendola et al. Back to school: use of Dried Blood Spot for the detection of SARS-CoV-2‑specific immunoglobulin G (IgG) among schoolchildren in Milan, Italy. medRxiv. 2020
  2. Beavis et al. Evaluation of the EUROIMMUN Anti-SARS-CoV-2 ELISA assay for detection of IgA and IgG antibodies. Journal of Clinical Virology 2020
  3. Behrens et al. Perceived versus proven SARS‑CoV‑2‑specific immune responses in health‑care professionals. Infection. 2020
  4. Bond et al. Evaluation of serological tests for SARS-CoV-2: Implications for serology testing in a low-prevalence setting. Preprint medRxiv. 2020
  5. Caturegli et al. Clinical Validity of Serum Antibodies to SARS-CoV-2 A Case–Control Study. Annals of Internal Medicine. 2020
  6. Charlton et al. Evaluation of 1 six commercial mid to high volume antibody and six point of care lateral flow assays for detection of SARS-CoV-2 antibodies. JCM. 2020
  7. Emmenegger et al. Population-wide evolution of SARS-CoV-2 immunity tracked by a ternary immunoassay. Preprint medRxiv 2020
  8. Emmerich et al. Limited specificity of commercially available SARS-CoV-2 IgG ELISAs in serum samples of African origin. medRxiv preprint, September 18, 2020 doi: 10.1101/2020.09.15.20159749
  9. GeurtsvanKessel et al. Towards the next phase: evaluation of serological assays for diagnostics and exposure assessment. Preprint medRxiv. 2020
  10. Harvala et al. Convalescent plasma therapy for the treatment of patients with COVID-19: Assessment of methods available for antibody detection and their correlation with neutralising antibody levels. Preprint medRxiv. 2020
  11. Harvala et al. Convalescent plasma treatment for SARS-CoV-2 infection: analysis of the first 436 donors in England, 22 April to 12 May 2020. Euro Surveill. 2020.
  12. Haselmann et al. Comparison of test performance of commercial anti-SARS-CoV-2 immunoassays in serum and plasma samples. Clinica Chimica Acta. 2020
  13. Herroelen et al. Kinetics of the humoral immune response to SARS-CoV-2: comparative analytical performance of seven commercial serology tests. medRxiv. 2020
  14. Hoerber et al. Evaluation of three fully-automated SARS-CoV-2 antibody assays. Clin Chem Lab Med. 2020.
  15. Infantino et al. Closing the serological gap in the diagnostic testing for COVID-19: The value of Anti-SARS-CoV-2 IgA antibodies. J Med Virol. 2020 Aug 13:10.1002/jmv.26422. doi: 10.1002/jmv.26422. Epub ahead of print.
  16. Kaltenbach et al. Initial characterisation of ELISA assays and the immune response of the clinically correlated SARS-CoV-2 biobank “SERO-BL-COVID-19” collected during the pandemic onset in Switzerland. medRxiv. 2020
  17. Knauer et al. Interim analysis of the Clinical performance of five SARS-Cov-2 Serology Assays. Clin Biochem. 2020 Sep 6:S0009-9120(20)30837-7. doi: 10.1016/j.clinbiochem.2020.09.002. Epub ahead of print.
  18. Kohmer et al. Clinical performance of SARS-CoV-2 IgG antibody tests and potential protective immunity. bioRxiv. 2020
  19. Lippi et al. Assessment of immune response to SARS-CoV-2 with fully automated MAGLUMI 2019-nCoV IgG and IgM chemiluminescence immunoassays. Clin Chem Lab Med. 2020
  20. Mahajan et al. Performance of Abbott Architect, Ortho Vitros, and Euroimmun Assays in Detecting Prior SARS-CoV-2 Infection. medRxiv. 2020
  21. Matushek et al. Evaluation of the EUROIMMUN Anti-SARS-CoV-2 ELISA Assay for detection of IgA and IgG antibodies. bioRxiv preprint. 2020
  22. Meyer et al. Validation of a commercially available SARS-CoV-2 serological immunoassay. Preprint medRxiv. 2020
  23. Montesinos et al. Evaluation of two automated and three rapid lateral flow immunoassays for the detection of anti-SARS-CoV-2 antibodies. J Clin Virol. 2020
  24. Orth-Höller et al. Kinetics of SARS-CoV-2 specific antibodies (IgM, IgA, IgG) in non-hospitalized patients four months following infection. Journal of Infection (2020), doi: doi.org/10.1016/j.jinf.2020.09.015
  25. Padoan et al. IgA-Ab response to spike glycoprotein of SARS-CoV-2 in patients with COVID-19: A longitudinal study. Clin Chim Acta 507:164-166. 2020
  26. Serrano et al. Comparison of commercial lateral flow immunoassays and ELISA for SARS-CoV-2 antibody detection. JCV. 2020
  27. Serre-Miranda et al. Performance assessment of 11 commercial serological tests for SARS-CoV-2 on hospitalized COVID-19 patients.
  28. Streeck et al. Infection fatality rate of SARS-CoV-2 infection in a German community with a super-spreading event. 2020 
  29. Stringhini et al. Repeated seroprevalence of anti-SARS-CoV-2 IgG antibodies in a population-based sample from Geneva, Switzerland. Preprint medRxiv 2020
  30. Tehrani et al. Specificity and Performance of Nucleocapsid and Spike-based SARS-CoV-2 Serologic Assays.
  31. Theel et al. Performance Characteristics of Four High-Throughput Immunoassays for Detection of IgG Antibodies against SARS-CoV-2. J Clin Microbiol. 2020
  32. Traugott et al. Performance of SARS-CoV-2 antibody assays in different stages of the infection: Comparison of commercial ELISA and rapid tests. Inf Dis. 2020
  33. Tré-Hardy et al. Validation of a chemiluminescent assay for specific SARS-CoV-2 antibody. Clin Chem Lab Med. 2020
  34. Valdivia et al. Inference of SARS-CoV-2 spike-binding neutralizing antibody titers in sera from hospitalized COVID-19 patients by using commercial enzyme and chemiluminescent immunoassays. medRxiv preprint, September 9, 2020 doi: 10.1101/2020.09.07.20188151
  35. Wechselberger et al. Performance evaluation of serological assays to determine the immunoglobulin status in SARSCoV-2 infected patients.
  36. Weidner et al. Quantification of SARS-CoV-2 antibodies with eight commercially available immunoassays. Journal of Clinical Virology. 2020
  37. Wolf et al. Monitoring antibody response following SARS-CoV-2 infection: Diagnostic efficiency of four automated immunoassays. Diagnostic Microbiology & Infectious Disease. 2020